One of may favorite places to get away to is Isle Royale National Park in lake Superior. Although the park is a pain to get to (either boat or seaplane), it has something for everybody once you are there. There are camp stores on each end of the island (for Mountain Dew, chocolate milk, and  showers!).

There are quite a few interior lakes that have decent fishing (not as good as the boundary waters, but good enough) and provide isolation. When I soloed a few years ago, I was alone on many of the lakes with the campgrounds and fishing to myself. Although most of the paddler's campsites are rustic, a few have rather nice lean-to shelters for the wet days.

There are lots of Moose on the island (it's almost impossible not te see any) and NO BEARS (although the mini-bears are about as ferocious and troublesome).

The portages are mostly tough, some are brutal due to the rough terrain. It is difficult to get to the interior lakes without at least one tough portage, but then the crowd is left behind.

Some routes are exposed to Lake Superior which can be a source of delay or may even a cause a route change. And those waters are always cold (no dumps allowed).