It's a matter of preference for the most part, butt if coming through this neighborhood, (i live near I-55 & I-355) I'd do the following:

I-65 > I-80 > I-355 > I-88 > I-39/90 (51)

Rush hour a.m.: most traffic is heading east and north
Rush hour p.m.: most traffic is heading south and west
I-88 near dekalb has a 2.00 toll but i still prefer to go this way

just looked at the map again, maybe 74 is a good way to go...avoid getting near the city...74 to I-39/90 (51) looks promising.