I used the Big Agnes Insulated Air Core mattress for 5 years and then switched to the Thermarest Neo Air, which I've been using for the last two seasons.  In either case I was using the same sized mattress (the longest and widest available.)  In terms of comfort, I found both models virtually identical, which is to say very comfortable.  However, if weight and volume are a concern then the Neo Air wins hands down.  Rolled up , it is at least half the size and more than half the weight of the BA.  That being said, you pay for that reduction so if that isn't that big an issue for you, you'll find the BA just as comfortable.