I did a little research on Opisquai a few years ago and while for a number of reasons I decided to forget it for at least a while, I did discover an outfitter serving that park -   (You need to Login or Register and talked with them by email.  My recollection is After the second email to one of the family in the business, the main lodge had a large fire and they were not able to respond for quite a while.  I thought at that time they could arrange a flight from Red hook for around $1000 for my son and I - round trip - but foggy memory.  I did find lots of maps and info and some nice appearing routes.

I guess until I've seen next to everyplace in the Q, I'll just wait, but the remoteness is appealing and if you fish, it seems like an amazing place.