I have used 12 lb PowerPro for years in Florida for skinny water and always use 3 to 4 feet of 20 lb Flourocarbon (Seaguar). I have used no knot except the Uni knot for 10 years and have not had a knot pull out. I use it Flouro to leader and on leader to lure.
I am going up to Quetico mid September for the first time and do have the dreaded yellow Powerpro on one of my reels. I'm frankly not worried about it, but if there is an issue and my son is catching more with the green, I will have a backup plan!