Wow I am glad that my dogs serve me well. Maybe they're just always used. Food and feet. For years I have "wet booted" running Redwing Irishsetters then various Irishsetter models( had to simple due to the fact that once the japanese fad fell on redwing I could not afford to due it any longer). They are always run with a good quality merino wool sock and a footbed. On occasion I due get minor blisters on the tops of my toes but only when the boot is wore out and stretched out and I am on a route with many ups and downs carrying profound weight. These are the boots that I wear everyday for work, and a average day for me is 10-12 miles shlepping the whole way-mmmmm a typical day in the crown or BW
I completely understand fit is paramount in foot ware; foot beds IMO can assist with that endeavor and are much more affordable than custom foot ware. I also ditch liner socks years ago because for me they simply caused more issues rather than doing what they are suppose to do...abraded blisters.
Last year I moved with great apprehension to a pair of Chotas(gore topped boots/model?) for a late season trip. No bisters due to the fact that I socked up the boot-one smartwool sock and one heavy weight filson with a boot bed to stiffen the sole and velcro strap around the ankle to keep the heel in the heal cup of the boot; because that is what my feet are use to. Yes, the footing was different but it is a different boot. But I was warm and that was the goal-warm.... not dry and warm. One of the byproducts of that switch up was lightening the mass on the foot, which was quite noticeable, even enjoyable, and belayed the stink factor

Knowing your foot ware and its limitations IMO are key-the gal that the boy and I came across last year on Alpine with a broken leg speaks loud and clear to that. IMO that can only be explored through trial and error to find the "system" that works for you-the individual-and then pushing the system in the circuit that is a mirror of the activity that is its application. Simply, if the hide is thin blisters will happen, if the boot dont fit dont wear it until it does, and slippage is about the soul/sole

The last thing is about Lasts...the "mold" that the foot ware is made on. Their are differences between american and european lasted boots. American style is wider....european is narrower in the heal cup and the like. This has me thinkin' about the pictures of the Borneo guides and their out of scale naked dogs that a employer showed me after he returned from a trip in search of P. rothschildianum in its native haunts.....support! it aint a loose term
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